Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

Author:

Dahmana Naoual,Mugnier Thibault,Gabriel Doris,Favez Tatiana,Kowalczuk Laura,Behar-Cohen Francine,Gurny Robert,Kalia Yogeshvar N.

Funder

Fondation Ernst et Lucie Schmidheiny

Kommission für Technologie und Innovation

Swiss Commission for Technology and Innovation

Université de Genève

Société Académique de Genève

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference49 articles.

1. Beneficial effect of spironolactone on androgenic alopecia;Adamopoulos;Clin. Endocrinol. (Oxf),1997

2. Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial;Afzali;J. Dermatol. Treat.,2012

3. Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris;Berardesca;Int. J. Tissue React.,1988

4. Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses;Boix;J, Invest. Dermatol.,2016

5. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne;Brown;Cochrane Database Syst. Rev.,2009

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