Affiliation:
1. Departamento de Ingeniería y Tecnología (Sección Farmacia), Facultad de Estudios Superiores Cuautitlán-
Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico
2. Division of Molecular
Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue,
Austin, TX 78712, USA
3. Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad
Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico
4. Unidad de Investigación
Multidisciplinaria-L 3, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México,
Carretera Cuautitlán-Teoloyucan, Cuautitlán Izcalli, 54714, Mexico
5. Área Académica de Medicina, Instituto de
Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla,
Hidalgo, 42160, Mexico
Abstract
Background:
Nanoparticle formulations development for anti-aging treatment is increasing
due to their multifunctional properties. These nanotechnological strategies can target cellular/
molecular pathways of the skin affected by the aging process. However, a review of these strategies
is required to discuss their efficacy/safety and establish the needs for further research.
Objective:
Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized
and discussed in this work.
Method:
The information in this review was extracted from recent and relevant studies using
nanotechnology for anti-aging treatment from scientific databases.
Results and Discussion:
Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles
of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes,
niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with
nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as,
flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin,
silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic,
rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus
aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other
compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin,
botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin
rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability,
and effectivity for skin anti-aging, providing a controlled drug release with minimized side
effects.
Conclusion:
Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles,
enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin.
Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the
clinic/industry.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biotechnology