Asymmetric synthesis of a neuroprotective and orally active N-methyl-d-aspartate receptor ion-channel blocker, CNS 5788

Author:

Padmanabhan Seetharamaiyer,Lavin Ruth C,Durant Graham J

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

Reference6 articles.

1. Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers

2. Durant, G. J.; Perlman, M. E.; Fischer, J. B.; Padmanabhan, S. PCT/US98/21395, 9 October, 1998.

3. Use of achiral shift reagents to indicate relative stabilities of diastereomeric solvates

4. Burkhart, B. M.; Duax, W. L., unpublished results.

5. (1R)-(−)-(10-Camphorsulfonyl)oxaziridine may be purchased from Aldrich Chemical Company, Inc.

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