Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers

Published:1997-12-01 Issue:26 Volume:40 Page:4281-4289
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hu Lain-Yen¹,Guo Junqing¹,Magar Sharad S.¹,Fischer James B.¹,Burke-Howie Kathleen J.¹,Durant Graham J.¹

Affiliation:

1. Cambridge NeuroScience, Inc., One Kendall Square, 700, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970459c

Reference31 articles.

1. (a) Watkins, J. C.; Collingridge, G. L. The NMDA Receptor: New Vistas. Oxford University Press: London, 1989; p 227−233.

2. The Role of Glutamate in Neurotransmission and in Neurologic Disease

3. Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

4. Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

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