Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch

Author:

Bremer Ryan E.,Baird Eldon E.,Dervan Peter B.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference56 articles.

1. Recognition of DNA by designed ligands at subnanomolar concentrations;Trauger;Nature,1996

2. Discrimination of 5′-GGGG-3′, 5′-GCGC-3′, and 5′-GGCC-3′ sequences in the minor groove of DNA by eight-ring hairpin polyamides;Swalley;J. Am. Chem. Soc.,1997

3. Recognition of 7 base-pair sequences in the minor groove of DNA by 10-ring pyrroleimidezole polyamides;Turner;J. Am. Chem. Soc.,1997

4. Design of peptides that bind in the minor groove of DNA at 5′-(A,T)5G(A,T)C(A,T) sequences by a dimeric side-by-side motif;Wade;J. Am. Chem. Soc.,1992

5. Antiparallel side-by-side motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin;Mrksich,1992

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