Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry
Reference37 articles.
1. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
2. Use of immobilized artificial membrane chromatography for drug transport applications††Abbreviations: blood-brain barrier, BBB; bovine brain microvessel endothelial cells, BBMEC; calculated log distribution coefficient (Pallas, CompuDrug, Budapest, Hungary), ClogD; calculated log partition coefficient, ClogP; capacity factor on an IAM column, k¢IAM; capacity factor on a reversed-phase column, k¢w; log distribution coefficient, log D; immobilized artificial membrane, IAM; nonsteroidal antiinflammatory, NSAID; octadecylsilicate, ODS; log octanol:water intrinsic partition coefficient, log P; phosphate-buffered saline, PBS; phosphatidylcholine, PC.
3. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
4. Comparison of passive drug transport through Caco-2 cells and artificial membranes
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