Use of immobilized artificial membrane chromatography for drug transport applications††Abbreviations: blood-brain barrier, BBB; bovine brain microvessel endothelial cells, BBMEC; calculated log distribution coefficient (Pallas, CompuDrug, Budapest, Hungary), ClogD; calculated log partition coefficient, ClogP; capacity factor on an IAM column, k¢IAM; capacity factor on a reversed-phase column, k¢w; log distribution coefficient, log D; immobilized artificial membrane, IAM; nonsteroidal antiinflammatory, NSAID; octadecylsilicate, ODS; log octanol:water intrinsic partition coefficient, log P; phosphate-buffered saline, PBS; phosphatidylcholine, PC.
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Published:1998-12
Issue:12
Volume:87
Page:1471-1478
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ISSN:0022-3549
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Container-title:Journal of Pharmaceutical Sciences
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language:en
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Short-container-title:Journal of Pharmaceutical Sciences
Author:
Stewart Barbra H.,Helen Chan O.
Publisher
American Geophysical Union (AGU)
Subject
Pharmaceutical Science
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3. Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds;Dressman;J. Pharm. Sci.,1985
4. Peptides and the Blood-Brain Barrier: Lipophilicity as a Predictor of Permeability;Banks;Brain Res. Bull.,1985
5. Relationship of Octanol/Water Partition Coefficient and Molecular Weight to Rat Brain Capillary Permeability;Levin;J. Med. Chem.,1980
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