Converting an injectable protein therapeutic into an oral form: Phenylalanine ammonia lyase for phenylketonuria

Author:

Kang Tse Siang,Wang Lin,Sarkissian Christineh N.,Gámez Alejandra,Scriver Charles R.,Stevens Raymond C.

Publisher

Elsevier BV

Subject

Endocrinology,Genetics,Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. K. Donlon, H. Levy, C.R. Scriver, Hyperphenylalaninemia: phenylalanine hydroxylase deficiency, in: The metabolic and molecular bases of inherited disease, McGraw-Hill/Medical Publishing Division, New York, 2007 (Chapter 77). Available from: .

2. Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase;Gamez;Molecular Therapy,2004

3. A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase;Sarkissian;Proceedings of the National Academy of Sciences of the United States of America,1999

4. Artificial cell-microencapsulated phenylalanine ammonia-lyase;Bourget;Applied Biochemistry and Biotechnology,1984

5. Phenylalanine ammonia lyase, enzyme substitution therapy for phenylketonuria, where are we now?;Sarkissian;Molecular Genetics and Metabolism,2005

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