Palladium(II) complexes bearing thiosemicarbazone and phosphines as inhibitors of DNA-Topoisomerase II enzyme: Synthesis, characterizations and biological studies

Author:

Lima Mauro Almeida,Costa Vinicius A.,Franco Mariane Araújo,de Oliveira Gabriela P.,Deflon Victor M.,Rocha Fillipe Vieira

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Elsevier BV

Subject

Materials Chemistry,Inorganic Chemistry,Physical and Theoretical Chemistry

Reference35 articles.

1. Topoisomerase II as a target for anticancer drugs: Wen enzymes stop being nice;Fortune;Prog. Nucleic Acid Res. Mol. Biol.,2000

2. DNA Topoisomerase and their poisonin by anticancer and antibacterial drugs;Pommier;Chem. Biol.,2010

3. Topoisomerase Iiα, rather than Iiβ, is a promising target in development of anti-cancer drugs;Chen;Drug. Discov. Ther.,2012

4. Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines;Fry;Cancer Res.,1991

5. A series of α-heterocyclic carboxaldehyde thiosemicarbazone inhibit topoisomerase Iiα activity;Huang;J. Med. Chem.,2010

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