Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd(<scp>ii</scp>) complexes-Reference-Cited by-同舟云学术

Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd(ii) complexes

Published:2024 Issue:11 Volume:53 Page:5073-5083
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Mansour Ahmed M.¹^ORCID,Khaled Rabaa M.²^ORCID,Radacki Krzysztof³^ORCID,Abo-Zeid Mona A. M.⁴⁵^ORCID,Shehab Ola R.²^ORCID,Mostafa Gamal A. E.⁶,Ali Essam A.⁶,Abo-Elfadl Mahmoud T.⁴⁷^ORCID

Affiliation:

1. Department of Chemistry, United Arab Emirates University, Al-Ain, United Arab Emirates

2. Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt

3. Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

4. Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt

5. Genetics and Cytology Department, Genetic Engineering and Biotechnology Research Institute, National Research Centre, Giza, Egypt

6. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

7. Biochemistry Department, Biotechnology Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt

Abstract

We report how the cytotoxicity, mode of death and genotoxic effect of a series of square planar Pd(ii) complexes are determined by the auxiliary ligand coupled to the Pd(ii) ion, which is chelated by the tridentate thiosemicarbazone ligand.

Funder

King Saud University

United Arab Emirates University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00032C

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