Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice

Author:

Siqueira Camila Monteiro12,Motta Priscila Dias3,Cardoso Thayná Neves3,de Paula Coelho Cideli34,Popi Ana Flavia5,Couceiro José Nelson1,Bonamin Leoni Villano34,Holandino Carla1

Affiliation:

1. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

2. Federal Institute of Rio de Janeiro, Brazil

3. Paulista University, São Paulo, Brazil

4. University of Santo Amaro, São Paulo, Brazil

5. Federal University of São Paulo, São Paulo, Brazil

Abstract

Background: Influenza affects thousands of people worldwide every year, motivating the development of new therapies. In this work, the effects of two homeopathic preparations (influenza biotherapies and thymulin) were chosen following two different rationales: isotherapy and endo-isotherapy models. The homeopathic effects were evaluated individually considering the inflammatory and behavioral responses against influenza virus antigen were studied in BALB/c mice.Methods: Male adult mice were treated orally and blindly for 21 days with highly diluted influenza virus or with thymulin, and were divided in two sets of experiments. The first series of experiments aimed to describe their behavior, using an open field (OF) device. In the second series, mice were challenged subcutaneously with influenza hemagglutinin antigen (7 μg/200 μl) at day 21. At day 42, behavior and inflammation response were evaluated.Results: No behavioral changes were seen in OF tests at any time point after treatments. Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge, varying according to treatment.Conclusion: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Georg Thieme Verlag KG

Subject

Complementary and alternative medicine

Reference29 articles.

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