2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A 2-Reference-Cited by-同舟云学术

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A 2

Published:2000-02 Issue:4 Volume:10 Page:395-398
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Boyd Helen F.,Flynn Sean T.,Hickey Deirdre M.B.,Ife Robert J.,Jones Martin,Leach Colin A.,Macphee Colin H.,Milliner Kevin J.,Rawlings D.Anthony,Slingsby Brian P.,Smith Stephen A.,Stansfield Ian G.,Tew David G.,Theobald Colin J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference9 articles.

1. The enzyme is also known as PAF acetyl hydrolase, though it is clear that the enzyme has much broader substrate specificity than this name implies. See Tew, D. G.; Southan, C.; Rice, S. Q. J.; Lawrence, M. P.; Haodong, L.; Boyd, H. F.; Moores, K.; Gloger, I. S.; Macphee, C. H. Atheroscler. Thromb. Vasc. Biol. 1996, 16 (4), 591. 3-Dimensional structural information on this enzyme is not available. Recently, the structure of a potentially related bacterial enzyme has been published: Wei, Y.; Swenson, L.; Castro, C.; Derewenda, U.; Minor, W.; Arai, H.; Aoki, J.; Inoue, K.; Servin-Gonzalez, L.; Derewenda, Z. S. Structure 1998, 6 (4), 511

2. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

3. Mechanism of Inhibition of LDL Phospholipase A2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry

4. Isocytosine H2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H1- and H2-receptors of 5-(heterocyclyl)methylisocytosines

5. Improved Synthesis of 5-Benzyl-2-thiouracils

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