Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening-Reference-Cited by-同舟云学术

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening

Published:2016-05-20 Issue:11 Volume:59 Page:5356-5367
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Woolford Alison J.-A.¹,Pero Joseph E.²,Aravapalli Sridhar²,Berdini Valerio¹,Coyle Joseph E.¹,Day Philip J.¹,Dodson Andrew M.²,Grondin Pascal³,Holding Finn P.¹,Lee Lydia Y. W.¹,Li Peng²,Manas Eric S.⁴,Marino Joseph⁴,Martin Agnes C. L.¹,McCleland Brent W.²,McMenamin Rachel L.¹,Murray Christopher W.¹,Neipp Christopher E.²,Page Lee W.¹,Patel Vipulkumar K.⁵,Potvain Florent³,Rich Sharna¹,Rivero Ralph A.²,Smith Kirsten¹,Somers Donald O.⁵,Trottet Lionel³,Velagaleti Ranganadh²,Williams Glyn¹,Xie Ren²

Affiliation:

1. Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom

2. GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

3. Centre de Recherches Francois Hyafil, GlaxoSmithKline, 25-27 Avenue du Québec, Les Ulis, France

4. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

5. GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00212

Reference49 articles.

1. The expanding superfamily of phospholipase A2 enzymes: classification and characterization

2. The phospholipase A2 superfamily and its group numbering system

3. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

4. Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies

5. Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study

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