A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

Author:

Tomaru Atsuko,Toshimoto Kota,Lee Wooin,Ishigame Keiko,Sugiyama Yuichi

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference30 articles.

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2. To apply microdosing or not? Recommendations to single out compounds with non-linear pharmacokinetics;Bosgra;Clin Pharmacokinet,2016

3. Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum;Canaparo;Clin Exp Pharmacol Physiol,2007

4. Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine;Berggren;Mol Pharm,2007

5. Prediction of nonlinear intestinal absorption of CYP3A4 and P-glycoprotein substrates from their in vitro Km values;Tachibana;Pharm Res,2012

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