Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance

Author:

Chen Huijun,Pui Yipshu,Liu Chengyu,Chen Zhen,Su Ching-Chiang,Hageman Michael,Hussain Munir,Haskell Roy,Stefanski Kevin,Foster Kimberly,Gudmundsson Olafur,Qian Feng

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference38 articles.

1. Oral formulation strategies to improve solubility of poorly water-soluble drugs;Singh;Expert Opin Drug Deliv,2011

2. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs;Vasconcelos;Drug Discov Today,2007

3. Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery;Brough;Int J Pharm,2013

4. The use of amorphous solid dispersions: a formulation strategy to overcome poor solubility and dissolution rate;Drug Discov Today Technol,2012

5. Characteristics and significance of the amorphous state in pharmaceutical systems;Hancock;J Pharm Sci,1997

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