“Negative” Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody

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“Negative” Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody–Drug Conjugates

Published:2024-08 Issue:8 Volume:113 Page:2433-2442
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Johann Florian,Wöll Steffen,Gieseler Henning^ORCID

Publisher

Elsevier BV

Reference40 articles.

1. UPLC-based assay to assess the hydrophobicity of antibody-drug conjugate (ADC) payloads;Pysz;J Chromatogr B,2020

2. Impact of payload hydrophobicity on the stability of antibody-drug conjugates;Buecheler;Mol Pharm,2018

3. Effect of linker-drug properties and conjugation site on the physical stability of ADCs;Mills;J Pharm Sci,2020

4. Optimization of drug-linker to enable long-term storage of antibody-drug conjugate for subcutaneous dosing;Hobson;J Med Chem,2023

5. Investigation of hydrophilic auristatin derivatives for use in antibody drug conjugates;Mendelsohn;Bioconjug Chem,2017

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