Impact of Payload Hydrophobicity on the Stability of Antibody–Drug Conjugates
Author:
Affiliation:
1. Division of Pharmaceutics, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Discovery and Development Technologies, Merck KGaA, 64293 Darmstadt, Germany
3. GILYOS GmbH, 97076 Würzburg, Germany
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00177
Reference39 articles.
1. Antibody Therapeutics in Cancer
2. Expanding the Reach of Antibody–Drug Conjugates
3. Current ADC Linker Chemistry
4. Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
5. A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography
Cited by 66 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Optimization of a pendant-shaped PEGylated linker for antibody-drug conjugates;Journal of Controlled Release;2024-11
2. Antibody–Calixarene Drug Conjugate: A General Drug Delivery Platform for Tumor-Targeted Therapy;ACS Applied Materials & Interfaces;2024-08-02
3. Evaluating the Potential of Cyclodextrins in Reducing Aggregation of Antibody–Drug Conjugates with Different Payloads;Journal of Pharmaceutical Sciences;2024-08
4. “Negative” Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody–Drug Conjugates;Journal of Pharmaceutical Sciences;2024-08
5. Understanding the Effects of Site-Specific Light Chain Conjugation on Antibody Structure Using Hydrogen Exchange-Mass Spectrometry (HX-MS);Journal of Pharmaceutical Sciences;2024-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3