In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults-Reference-Cited by-同舟云学术

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Published:2022-01 Issue:1 Volume:111 Page:197-205
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Pentafragka Christina,Tomaszewska Irena,Bellmann Susann,Minekus Mans,Schilderink Ronald^ORCID,Vertzoni Maria^ORCID,McAllister Mark,Reppas Christos^ORCID

Funder

Horizon 2020

Pfizer

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference31 articles.

1. A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine;Minekus;ATLA,1995

2. Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol;Minekus;Biosci Biotechnol Biochem,2005

3. Influence of surfactants on lipase fat digestion in a model gastrointestinal system;Reis;Food Biophys,2008

4. Lipid digestion of protein stabilized emulsions investigated in a dynamic in vitro gastro-intestinal model system;Helbig;Food Dig,2013

5. Application and validation of an advanced gastrointestinal in vitro model for the evaluation of drug product performance in pharmaceutical development;Barker;J Pharm Sci,2014

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