Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference34 articles.
1. On the rate and extent of drug delivery to the brain;Hammarlund-Udenaes;Pharm Res,2008
2. Assessment of the blood-brain barrier in CNS drug discovery;Jeffrey;Neurobiol Dis,2010
3. In vivo, in vitro and in silico methods for small molecule transfer across the blood brain barrier;Mensch;J Pharm Sci,2009
4. Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling;Wager;Exp Opin Drug Metabolism Toxicol,2012
5. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system;Feng;Drug Metab Dispos,2008
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Applicability of MDR1 Overexpressing Abcb1KO-MDCKII Cell Lines for Investigating In Vitro Species Differences and Brain Penetration Prediction;Pharmaceutics;2024-05-29
2. CNS penetration of methotrexate and its metabolite 7-hydroxymethotrexate in mice bearing orthotopic Group 3 medulloblastoma tumors and model-based simulations for children;Drug Metabolism and Pharmacokinetics;2023-02
3. Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans;Biopharmaceutics & Drug Disposition;2023-02
4. Recent advances in the in vitro and in vivo methods to assess impact of P‐glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition;Biopharmaceutics & Drug Disposition;2023-02
5. Evaluation of bottom‐up modeling of the blood–brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling;Biopharmaceutics & Drug Disposition;2023-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3