Application of platform process development approaches to the manufacturing of Mabcalin™ bispecifics

Author:

Wachter Stefanie,Angevin Thibaut,Bubna NiketORCID,Tan Adelene,Cichy Adam,Brown DavidORCID,Wolfe Leslie S.,Sappington RyanORCID,Lilla Edward,Berry Luke,Grismer DaneORCID,Orth Christian,Blanusa MilanORCID,Mostafa Sigma,Kaufmann Hitto,Felderer Karin

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology,Bioengineering

Reference39 articles.

1. Lipocalins;Åkerström,2006

2. An integrated approach to aggregate control for therapeutic bispecific antibodies using an improved three column mab platform-like purification process;Andrade;Biotechnol. Prog.,2019

3. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies;Ascierto;Semin Oncol.,2010

4. Bispecific T-cell engaging antibodies for cancer therapy;Baeuerle;Cancer Res,2009

5. Current trends and challenges in the downstream purification of bispecific antibodies;Chen;Antib. Ther.,2021

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