Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial

Author:

Leichman L,Lenz H.-J,Leichman C.G,Groshen S,Danenberg K,Baranda J,Spears C.P,Boswell W,Silberman H,Ortega A,Stain S,Beart R,Danenberg P

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference28 articles.

1. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma;Poon;J Clin Oncol,1989

2. A randomized phase I and II study of short-term infusion of high dose fluorouracil with or without n-(phosphonacetyl)-l-aspartic acid in patients with advanced pancreatic and colorectal cancers;Ardalan;J Clin Oncol,1988

3. Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma;Wadler;J Clin Oncol,1989

4. Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil;Evans;Cancer Res,1981

5. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil;Berger;Mol Pharmac,1984

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