A phase II study of piritrexim in patients with advanced squamous cell carcinoma of the head and neck

Author:

Degardin M.,Domenge C.,Cappelaere P.,Luboinski B.,Navarrete M.S.,Scott J.E.,Lefebvre J.-L.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference8 articles.

1. Biochemical and chemotherapeutic studies on 2, 4-diamino -6/2,5 dimethoxybenzyl/5-methylpyrido /2,3-d/pyrimidine/BW 301 U/, a novel lipidsoluble inhibitor of dihydrofolate reductase;Duch;Cancer Res,1982

2. Metabolic inhibition by a new antifolate 2,4-diamino-6/2,5-dimethoxybenzyl/-5-methylpyrido / 2,3-d/pyrimidine /BW 301 U/, an effective inhibitor of human lymphoid and dihydrofolate reductase over producing mouse cell lines;Sedwick;Mol Pharmacol,1982

3. A phase I clinical and pharmacological study of weekly intravenous infusions of Piritrexim /BW 301 U/;Weiss;Eur J Cancer Clin Oncol,1989

4. Phase I trial of Piritrexim capsules using prolonged low-dose oral administration for the treatment of advanced malignancies;Feun;J Natl Cancer Inst,1991

5. Pediatric phase I trial, pharmacokinetic study and limited sampling strategy for Piritrexim administered on a low-dose, intermittent schedule;Adamson;Cancer Res,1992

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