Phase I Study of Piritrexim and Gemcitabine in Patients With Advanced Solid Tumors

Author:

Huie Michael,Carducci Michael,Liu Glenn,Wilding George,Marnocha Rebecca,Izquierda Miguel,Thomas James

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cancer Research,Oncology

Reference22 articles.

1. The pharmacology and clinical use of methotrexate.;Jolivet;N Engl J Med,1983

2. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.;De Graaf;Proc Natl Acad Sci U S A,1996

3. Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido(2,3-d) pyrimidine (BW301U) a novel lipid soluble inhibitor of dihydrofolate reductase.;Duch;Cancer Res,1982

4. Comparison of activity of lipid soluble pyrido-pyrimidine BW301U and methotrexate against human tumor colony forming units.;Neuenfeldt;Proc Am Soc Clin Oncol,1982

5. Phase I trial of piritrexim capsules using prolonged, low dose oral administration for the treatment of advanced malignancies.;Feun;J Natl Cancer Inst,1991

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Piritrexim;Meyler's Side Effects of Drugs;2016

2. Molecular basis of antifolate resistance;Cancer and Metastasis Reviews;2007-02-27

3. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis;Drug Resistance Updates;2006-08

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