The effectiveness of the O6-alkylguanine-DNA alkyltransferase encoded by the ogtST gene from S. typhimurium in protection against alkylating drugs, resistance to O6-benzylguanine and sensitisation to dibromoalkane genotoxicity

Author:

Abril Nieves,Luque-Romero Franscisco L,Yamada Masami,Nohmi Takehiko,Pueyo Carmen

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference36 articles.

1. Mechanisms of carcinogenesis induced by alkylating agents;Saffhill;Biochim. Biophys. Acta,1985

2. Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase;Lindahl;EMBO J.,1982

3. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma;Friedman;J. Clin. Oncol.,1998

4. Repair of O6-alkylguanine by alkyltransferases;Pegg;Mutat. Res.,2000

5. Chemoprotection of normal tissues by transfer of drug resistance genes;Rafferty;Cancer Metastasis Rev.,1996

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