Secondary pharmacology: screening and interpretation of off-target activities – focus on translation

Author:

Whitebread Steven,Dumotier Berengere,Armstrong Duncan,Fekete Alexander,Chen Shanni,Hartmann Andreas,Muller Patrick Y.,Urban Laszlo

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference76 articles.

1. In vitro safety pharmacology profiling: an essential tool for successful drug development;Whitebread;Drug Discov. Today,2005

2. ICH Expert Working Group. Safety pharmacology studies for human pharmaceuticals S7A. Available at: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7A/Step4/S7A_Guideline.pdf

3. Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective;Papoian;Nat. Rev. Drug Discov.,2015

4. Screening for safety-relevant off-target activities;Urban,2012

5. Reducing safety-related drug attrition: the use of in vitro pharmacological profiling;Bowes;Nat. Rev. Drug Discov.,2012

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