Current screening, design, and delivery approaches to address low permeability of chemically synthesized modalities in drug discovery and early clinical development-Reference-Cited by-同舟云学术

Current screening, design, and delivery approaches to address low permeability of chemically synthesized modalities in drug discovery and early clinical development

Published:2023-09 Issue:9 Volume:28 Page:103685
ISSN:1359-6446
Container-title:Drug Discovery Today
language:en
Short-container-title:Drug Discovery Today

Author:

Yang Wenzhan^ORCID,Lipert Maya,Nofsinger Rebecca

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference98 articles.

1. The evolving druggability and developability space: chemically modified new modalities and emerging small molecules;Yang;AAPS J,2020

2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings;Lipinski;Adv Drug Deliv Rev,1997

3. Beyond the rule of 5: lessons learned from AbbVie's drugs and compound collection;DeGoey;J Med Chem,2018

4. Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and supersaturation in the digestive aqueous phase;Mondal;Int J Pharm,2023

5. The critical role of passive permeability in designing successful drugs;Di;ChemMedChem,2020

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