Comparative evaluation of 4 and 6-carbon spacer conformationally flexible tetrahydroisoquinolinyl benzamide analogues for imaging the sigma-2 receptor status of solid tumors

Author:

Lee Iljung,Lieberman Brian P.,Li Shihong,Hou Catherine,Makvandi Mehran,Mach Robert H.

Funder

DOE

Publisher

Elsevier BV

Subject

Cancer Research,Radiology Nuclear Medicine and imaging,Molecular Medicine

Reference45 articles.

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2. sigma Opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in Guinea pig brain membranes;Tam;Proc Natl Acad Sci U S A,1984

3. Sigma receptors: biology and function;Walker;Pharmacol Rev,1990

4. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of Guinea pig brain;Hellewell;Brain Res,1990

5. A proposal for the classification of sigma binding sites;Quirion;Trends Pharmacol Sci,1992

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