PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression-Reference-Cited by-同舟云学术

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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

Published:2019-04 Issue:1 Volume:27 Page:294-306.e5
ISSN:2211-1247
Container-title:Cell Reports
language:en
Short-container-title:Cell Reports

Author:

Toska Eneda,Castel Pau,Chhangawala Sagar,Arruabarrena-Aristorena Amaia,Chan Carmen,Hristidis Vasilis C.,Cocco Emiliano,Sallaku Mirna,Xu Guotai,Park Jane,Minuesa Gerard,Shifman Sophie G.,Socci Nicholas D.,Koche Richard,Leslie Christina S.,Scaltriti Maurizio,Baselga José

Funder

National Science Foundation

Jane Coffin Childs Memorial Fund for Medical Research

National Institutes of Health

V Foundation for Cancer Research

Breast Cancer Research Foundation

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference49 articles.

1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha;Alessi;Curr. Biol,1997

2. New insights into mTOR signaling: mTORC2 and beyond;Alessi;Sci. Signal.,2009

3. The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth;Bago;EMBO J.,2016

4. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1;Biggs;Proc. Natl. Acad. Sci. USA,1999

5. Trimmomatic: a flexible trimmer for Illumina sequence data;Bolger;Bioinformatics,2014

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