Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation

Author:

Li Yingchun,Qu Xiujuan,Qu Jinglei,Zhang Ye,Liu Jing,Teng Yuee,Hu Xuejun,Hou Kezuo,Liu Yunpeng

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference38 articles.

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2. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML–RAR alpha/PML proteins;Chen;Blood,1996

3. The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future;Evens;Leukemia Res.,2004

4. Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH;Han;Cancer Lett.,2008

5. The effect of arsenic trioxide (As2O3) on proliferation and cell cycle in gastric cancer cell line BGC823;Li;J. Oncol.,2008

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