Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity
Author:
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
Reference18 articles.
1. 2,4-Dinitro-5- ethyleneiminobenzamide (CB1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256;Cobb;Biochem Pharmacol,1969
2. The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink;Friedlos;Biochem Pharmacol,1992
3. CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells;Roberts;Biochem Biophvs Res Commun,1986
4. A new cytotoxic DNA interstrand crosslinking agent 5-(aziridin-1 -yl)-4-hydroxylamino-2-nitrobenzamide is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells;Knox;Biochem Pharmacol,1988
5. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-l-yl)-2,4-dinitro-benzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxyl- amino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2);Knox;Biochem Pharmacol,1988
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3. Quinone reductase 2 substrate specificity and inhibition pharmacology;Chemico-Biological Interactions;2005-02
4. Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications;Methods in Enzymology;2004
5. CB 1954: From the Walker Tumor to NQO2 and VDEPT;Current Pharmaceutical Design;2003-10-01
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