Quinone Oxidoreductase-2–Mediated Prodrug Cancer Therapy-Reference-Cited by-同舟云学术

Quinone Oxidoreductase-2–Mediated Prodrug Cancer Therapy

Published:2010-07-14 Issue:40 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Middleton Mark R.¹,Knox Richard²,Cattell Emma¹,Oppermann Udo³⁴,Midgley Rachel⁵,Ali Raghib⁵,Auton Tim²,Agarwal Roshan⁶,Anderson David⁵,Sarker Debashis⁶,Judson Ian⁶,Osawa Tsuyoshi⁷,Spanswick Victoria J.⁷,Davies Scot⁸,Hartley John A.⁷,Kerr David J.⁵⁹

Affiliation:

1. Department of Medical Oncology, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.

2. BTG, 5 Fleet Place, London EC4M 7RD, UK.

3. Structural Genomics Consortium, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK.

4. Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Biomedical Research Unit, Oxford OX3 7LD, UK.

5. Department of Clinical Pharmacology, University of Oxford, Headington, Oxford OX3 7DQ, UK.

6. Drug Development Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK.

7. Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

8. Drug Development Office, Cancer Research UK, 61 Lincoln’s Inn Fields, London WC2A 3PX, UK.

9. SIDRA Medical and Research Centre, P.O. Box 26999, Doha, Qatar.

Abstract

An oxidoreductase enzyme, abundant in tumors, can be catalytically activated by a synthetic cofactor to convert a prodrug to a cytotoxic DNA binding species in human subjects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference16 articles.

1. Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)

2. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: A novel co-substrate-mediated antitumor prodrug therapy.;Knox R. J.;Cancer Res.,2000

3. CB 1954: From the Walker Tumor to NQO2 and VDEPT

4. Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A phase I and pharmacokinetic study of its prodrug, CB1954.;Chung-Faye G.;Clin. Cancer Res.,2001

5. Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

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