The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers

Author:

Wortelboer H.M.,de Kruif C.A.,van Iersel A.A.J.,Falke H.E.,Noordhoek J.,Blaauboer B.J.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference36 articles.

1. P450 genes: structure, evolution, and regulation;Nebert;Annu Rev Biochem,1987

2. Induction of microsomal cytochrome P-450 enzymes;Conney;Life Sci,1986

3. Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochernical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone;Guengerich;Biochemistry,1982

4. Comparison of model systems for metabolism.;Moldeus,1987

5. Use of isolated and cultured hepatocytes for xenobiotic and cytotoxicity studies;Guillouzo,1986

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