Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5-ethyl-2′-deoxyuridine and 5-(2-chloroethyl)-2′-deoxyuridine-Reference-Cited by-同舟云学术

Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2′-deoxyuridine, 5-ethyl-2′-deoxyuridine and 5-(2-chloroethyl)-2′-deoxyuridine

Published:1986-05 Issue:10 Volume:35 Page:1647-1653
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Desgranges C.,De Clercq E.,Razaka G.,Drouillet F.,Belloc I.,Bricaud H.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference24 articles.

1. Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines

2. Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets

3. Inhibition of thymidine phosphorylase by 6-aminothymine and derivatives of 6-aminouracil

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2. Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats;European Journal of Drug Metabolism and Pharmacokinetics;1991-04

3. cis-trans-Isomerization of [E]-5-(2-bromovinyl)-2,2′-anhydrouridinein vivoin rats;Xenobiotica;1991-01

4. Inhibition of uridine phosphorylase by pyrimidine nucleoside analogs and consideration of substrate binding to the enzyme based on solution conformation as seen by NMR spectroscopy;European Journal of Biochemistry;1988-12

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