Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell

Author:

Seither Richard L.,Rape Tracy J.,Goldman I.David

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

1. Selectivity of glycine, adenosine and thymidine protection of granulocytic progenitor cells versus tumor cells against MTX cytotoxicity in vitro: Correlation with the formation of MTX polyglutamate derivatives;Fabre;Cancer Res,1984

2. Analysis of the role of membrane transport and polyglutamylation of MTX in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity;Fry;Cancer Res,1983

3. Formation of MTX polyglutamates in purified myeloid precursor cells from normal human bone marrow;Koizumi;J Clin Invest,1985

4. Synthesis, retention and biological activity of MTX polyglutamates in cultured human breast cancer cells;Jolivet;J Clin Invest,1982

5. Evidence for the cytotoxic activity of polyglutamate derivatives of MTX;Galivan;Mol Pharmacol,1980

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