Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies
Author:
Publisher
Elsevier BV
Subject
Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology
Reference64 articles.
1. Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody;Asano;Protein Eng Des Sel,2013
2. Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity;Asano;Oncotarget,2018
3. Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics;Asano;mAbs,2014
4. CD20-TCB with obinutuzumab pretreatment as next-generation treatment of hematologic malignancies;Bacac;Clin Cancer Res,2018
5. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody;Bargou;Science,2008
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