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Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?

  • Published:2016 Issue: Volume:14 Page:304-308
  • ISSN:2001-0370
  • Container-title:Computational and Structural Biotechnology Journal
  • language:en
  • Short-container-title:Computational and Structural Biotechnology Journal

Author:

Marschall Andrea L.J.,Dübel Stefan

Funder

foundation Peter und Traudl Engelhorn-Stiftung zur Förderung der Biotechnologie und Gentechnologie (Germany)

Publisher

Elsevier BV

Subject

Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology

Reference56 articles.

1. In vivo antitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16;Accardi;Int J Cancer,2014

2. A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models;Amici;Oncotarget,2016

3. Antigen-independent selection of intracellular stable antibody frameworks;Auf der Maur;Methods,2004

4. ER-targeted intrabodies mediating specific in vivo knockdown of transitory proteins in comparison to RNAi;Backhaus,2016

5. The proton sponge: A trick to enter cells the viruses did not exploit;Behr;Chimia,1997
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