Long-Timescale Simulations Revealed Critical Non-Conserved Residues of Phosphodiesterases Affecting Selectivity of BAY60-7550
Author:
Publisher
Elsevier BV
Subject
Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology
Reference62 articles.
1. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments;Keravis;Br J Pharmacol,2012
2. PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration;Fleming;J Cell Sci,2004
3. Phosphodiesterase inhibition in heart failure;Movsesian;Heart Fail Rev,2009
4. Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia;Charych;J Neurosci,2010
5. Structure-guided design and procognitive assessment of a potent and selective phosphodiesterase 2a inhibitor;Stachel;ACS Med Chem Lett,2018
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