Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Author:
Affiliation:
1. Merck & Co. Inc., P.O. Box 4, West Point, Pennsylvania 19486, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00214
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1. Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status
2. PDE2 inhibition: Potential for the treatment of cognitive disorders
3. Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease
4. Characterization of human phosphodiesterase 12 and identification of a novel 2′-5′ oligoadenylate nuclease – The ectonucleotide pyrophosphatase/phosphodiesterase 1
5. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
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