Development of a practical synthesis to PI3K α-selective inhibitor GDC-0326
Author:
Funder
Genentech
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
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4. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation;Furet;Bioorg. Med. Chem. Lett.,2013
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1. Synthesis, mesomorphic and fluorescent properties of 1,3,4-oxadiazoles/thiadiazoles with a terminal 3-fluoro-4-cyanophenyl group;Tetrahedron;2023-09
2. Seven-membered rings;Progress in Heterocyclic Chemistry;2023
3. Challenges in the structure determination of a dimeric impurity found during development of GDC-0326;Journal of Pharmaceutical and Biomedical Analysis;2022-05
4. Synthesis of GDC-0326;Synfacts;2021-04-20
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