Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)-Reference-Cited by-同舟云学术

Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

Published:2016-06-16 Issue:14 Volume:11 Page:1517-1530
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Scott William J.¹,Hentemann Martin F.²,Rowley R. Bruce²,Bull Cathy O.²,Jenkins Susan²,Bullion Ann M.²,Johnson Jeffrey²,Redman Anikó²,Robbins Arthur H.²,Esler William²,Fracasso R. Paul²,Garrison Timothy²,Hamilton Mark²,Michels Martin³,Wood Jill E.²,Wilkie Dean P.²,Xiao Hong²,Levy Joan²,Stasik Enrico⁴,Liu Ningshu⁴,Schaefer Martina⁵,Brands Michael⁶,Lefranc Julien⁶

Affiliation:

1. Global Development; Global Program Management; Bayer HealthCare Pharmaceuticals Inc.; Whippany NJ 07981 USA

2. Former Bayer Research Center; West Haven CT 16516 USA

3. Global Drug Discovery; Project Management Drug Discovery; Bayer Pharma AG; 13353 Berlin Germany

4. Global Drug Discovery; TRG Oncology; Bayer Pharma AG; 13353 Berlin Germany

5. Global Drug Discovery; Structural Biology; Bayer Pharma AG; 13353 Berlin Germany

6. Global Drug Discovery; Medicinal Chemistry Berlin; Bayer Pharma AG; 13353 Berlin Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference43 articles.

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2. Molecules in medicine mini-review: isoforms of PI3K in biology and disease

3. Targeting PI3 kinase in cancer

4. Signaling by Distinct Classes of Phosphoinositide 3-Kinases

5. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

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