Identification, characterization, synthesis and strategy for minimization of potential impurities observed in the synthesis of brivaracetam

Author:

Liao Shouzhu,Chen Hongjun,Wang Guifei,Wu Shuming,Yang Zaiyou,Luo Weihe,Liu Zhuanfeng,Gao Xun,Qin Junhai,Li Chuan-hua,Wang Zhongqing

Funder

State Key Laboratory of Anti-Infective Drug Development

Key research and development program of Guangdong Province, China

Hunan Provincial Natural Science Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference23 articles.

1. A review in partial-onset (focal) seizures in patients with epilepsy;Hoy;CNS Drugs,2016

2. Brivaracetam: first global approval;Markham;Drugs,2016

3. 4-Substituted pyrrolidin-2-ones and their use;Ates;PCT Int. Patent Appl. WO 2007/031263 A1,2007

4. 2-Oxo-1-Pyrrolidine derivatives, processes for preparing them and their uses;Differding;PCT Int. Patent Appl. WO2001/062726A2,2001

5. Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity;Kenda;J. Med. Chem.,2004

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