An efficient stereoselective synthesis of six stereoisomers of 3, 4-diaminocyclohexane carboxamide as key intermediates for the synthesis of factor Xa inhibitors-Reference-Cited by-同舟云学术

An efficient stereoselective synthesis of six stereoisomers of 3, 4-diaminocyclohexane carboxamide as key intermediates for the synthesis of factor Xa inhibitors

Published:2017-03 Issue:11 Volume:73 Page:1381-1388
ISSN:0040-4020
Container-title:Tetrahedron
language:en
Short-container-title:Tetrahedron

Author:

Wang Xin,Ma Mingliang,Reddy Alavala Gopi Krishna,Hu Wenhao

Funder

NSF

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference28 articles.

1. Surface-dependent reactions of the vitamin K-dependent enzyme complexes

2. Importance of factor Xa in determining the procoagulant activity of whole-blood clots.

3. Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation

4. Edoxaban Tosylate

5. Edoxaban

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