Application of a novel drug-tolerant target assay for measuring target engagement when only one epitope remains after therapeutic antibodies bind their targets-Reference-Cited by-同舟云学术

Application of a novel drug-tolerant target assay for measuring target engagement when only one epitope remains after therapeutic antibodies bind their targets

Published:2021-02 Issue: Volume:489 Page:112916
ISSN:0022-1759
Container-title:Journal of Immunological Methods
language:en
Short-container-title:Journal of Immunological Methods

Author:

Carter Quincy L.,Siegel Robert W.,Qian Yuewei,Konrad Robert J.

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference13 articles.

1. Properties of a general PK/PD model of antibody-ligand interactions for therapeutic antibodies that bind to soluble endogenous target;Davda;MAbs.,2010

2. A novel method for quantitative measurement of a biomarker in the presence of a therapeutic monoclonal antibody directed against the biomarker;Davis;J. Pharm. Biomed. Anal.,2008

3. Analytical assay platforms for soluble target engagement biomarkers: old favorites and emerging technologies;Goodman;Bioanalysis.,2013

4. Bioanalytical approaches to quantify “total” and “free” therapeutic antibodies and their targets: technical challenges and PK/PD applications over the course of drug development;Lee;AAPS. J.,2011

5. Novel approaches using alkaline or acid/guanidine treatment to eliminate therapeutic antibody interference in the measurement of total target ligand;Salimi-Moosavi;J. Pharm. Biomed. Anal.,2010

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