Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4ʹ-modified nucleoside RT inhibitors-Reference-Cited by-同舟云学术

Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4ʹ-modified nucleoside RT inhibitors

Published:2019-02 Issue:4 Volume:509 Page:943-948
ISSN:0006-291X
Container-title:Biochemical and Biophysical Research Communications
language:en
Short-container-title:Biochemical and Biophysical Research Communications

Author:

Yasutake Yoshiaki^ORCID,Hattori Shin-ichiro,Tamura Noriko,Matsuda Kouki,Kohgo Satoru,Maeda Kenji^ORCID,Mitsuya Hiroaki

Funder

Japan Agency for Medical Research and Development (AMED

Japan Society for the Promotion of Science (JSPS-KAKENHI

National Center for Global Health and Medicine, Japan

Intramural Research Program of the Center for Cancer Research

National Cancer Institute

National Institutes of Health, USA

Drug Discovery and Life Science Research

Innovative Drug Discovery and Life Science Research

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

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4. 4ʹ-Modified nucleoside analogs: potent inhibitors active against entecavir resistant hepatitis B virus;Takamatsu;Hepatology,2015

5. Structural basis of HIV inhibition by translocation defective RT inhibitor 4ʹ-ethynyl-2-fluoro-2ʹ-deoxyadenosine (EFdA);Salie;Proc. Natl. Acad. Sci. U.S.A.,2016

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