Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations-Reference-Cited by-同舟云学术

Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations

Published:2021-07-26 Issue:16 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nakajima Shogo¹²³,Watashi Koichi¹²⁴⁵,Kato Takanobu¹,Muramatsu Masamichi¹,Wakita Takaji¹,Tamura Noriko⁶,Hattori Shin-ichiro⁷,Maeda Kenji⁷,Mitsuya Hiroaki⁷⁸,Yasutake Yoshiaki⁶⁹^ORCID,Toyoda Tetsuya³^ORCID

Affiliation:

1. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Applied Biological Science, Tokyo University of Science, Noda, Japan

3. Choju Medical Institute, Toyohashi, Japan

4. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

5. MIRAI, Japan Science and Technology Agency, Saitama, Japan

6. Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Sapporo, Japan

7. National Center for Global Health and Medicine Research Institute, Tokyo, Japan

8. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

9. Computational Bio Big-Data Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

Abstract

HBV infects 257 million people in the world, who suffer from elevated risks of liver cirrhosis and cancer. ETV is one of the most potent anti-HBV drugs, and ETV resistance mutations in HBV RT have been extensively studied.

Funder

MEXT | Japan Society for the Promotion of Science

National Center for Global Health and Medicine

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02401-20

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