Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecan

Author:

Tsurutani Junji,Nitta Takashi,Hirashima Tomonori,Komiya Takefumi,Uejima Hisao,Tada Hirohito,Syunichi Negoro,Tohda Aritomo,Fukuoka Masahiro,Nakagawa Kazuhiko

Publisher

Elsevier BV

Subject

Cancer Research,Pulmonary and Respiratory Medicine,Oncology

Reference22 articles.

1. Irinotekan in small-cell lung cancer-Japanese trials;Fukuoka;Oncology,2000

2. A phase II study of irinotecan combined with cisplatin in non-small cell lung cancer;Nagao;Gan To Kagaku Ryoho,2000

3. Salts LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, for the Irinotecan Study Group. Irinotecan plus fluorouracil and leucovorin for metasitatic colorectal cancer. New Engl J Med 2000;243(13):905–914.

4. Mutation at the catalytic site of topoisomerase I CEM/C2, a human leukemia cell line resistant to camptothecin;Fujimori;Cancer Res.,1995

5. Identification of a mutant topoisomerase I with intact catalatic activity and resistance to 9-nitrocamptothecin;Rubin;J. Biol. Chem.,1994

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