Prediction of Thorough QT study results using action potential simulations based on ion channel screens

Author:

Mirams Gary R.,Davies Mark R.,Brough Stephen J.,Bridgland-Taylor Matthew H.,Cui Yi,Gavaghan David J.,Abi-Gerges Najah

Funder

EPSRC

Microsoft Research

NC3Rs/EPSRC

Wellcome Trust

Royal Society

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference38 articles.

1. Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge;Beattie;Journal of Pharmacological and Toxicological Methods,2013

2. Multiscale modelling of drug-induced effects on cardiac electrophysiological activity;Brennan;European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences,2009

3. In vitro and in vivo models for testing arrhythmogenesis in drugs;Carlsson;Journal of Internal Medicine,2006

4. Considerations for the use of cellular electrophysiology models within cardiac tissue simulations;Cooper;Progress in Biophysics and Molecular Biology,2011

5. High-throughput functional curation of cellular electrophysiology models;Cooper;Progress in Biophysics and Molecular Biology,2011

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