Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints

Author:

Jenkinson Stephen,Goody Susan M.G.,Bassyouni Asser,Jones Rhys,Otto-Bruc Annie,Duquennoy Stephanie,DaSilva Jamie K.,Butler Paul,Mead Andy

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference24 articles.

1. Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS guide to pharmacology database;Abood,2019

2. Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding;Banker;Journal of Pharmaceutical Sciences,2003

3. Safety screening in early drug discovery: An optimized assay panel;Bendels;Journal of Pharmacological and Toxicological Methods,2019

4. Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists;Bosier;Neuropharmacology,2010

5. Reducing safety-related drug attrition: The use of in vitro pharmacological profiling;Bowes;Nature Reviews Drug Discovery,2012

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