Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern

Author:

Kirsch Glenn E.,Trepakova Elena S.,Brimecombe Jessica C.,Sidach Serguei S.,Erickson Hope D.,Kochan Mary C.,Shyjka Lisa M.,Lacerda Antonio E.,Brown Arthur M.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference34 articles.

1. Drug-induced long QT syndrome: Is HERG the root of all evil?;Brown;Pharmaceutical News,2000

2. Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs;Chouabe;Therapie,2000

3. Loratadine blockade of K+ channels in human heart: Comparison with terfenadine under physiological conditions;Crumb;Journal of Pharmacology and Experimental Therapeutics,2000

4. Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes;Daleau;Circulation,1995

5. Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current;Drolet;Journal of Pharmacology and Experimental Therapeutics,1999

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