CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model-Reference-Cited by-同舟云学术

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CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model

Published:2019-09 Issue: Volume:17 Page:829-839
ISSN:2162-2531
Container-title:Molecular Therapy - Nucleic Acids
language:en
Short-container-title:Molecular Therapy - Nucleic Acids

Author:

Ekman Freja K.,Ojala David S.,Adil Maroof M.,Lopez Paola A.,Schaffer David V.,Gaj Thomas

Funder

Ruth L. Kirschstein National Research Service Award

Judith and Jean Pape Adams Charitable Foundation

NSF

UC Berkeley

NIH

Publisher

Elsevier BV

Subject

Drug Discovery,Molecular Medicine

Reference88 articles.

1. Huntington disease;Bates;Nat. Rev. Dis. Primers,2015

2. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes;MacDonald;Cell,1993

3. Nuclear and neuropil aggregates in Huntington’s disease: relationship to neuropathology;Gutekunst;J. Neurosci.,1999

4. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington’s disease brains, associate with membranes, and undergo calpain-dependent proteolysis;Kim;Proc. Natl. Acad. Sci. USA,2001

5. Mutant huntingtin disrupts the nuclear pore complex;Grima;Neuron,2017

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